Temporal- and Location-Specific Alterations of the GABA Recycling System in Mecp2 KO Mouse Brains. Kang SK, Kim ST, Johnston MV, Kadam SD (2014). Twenty-four hour quantitative-EEG and in-vivo glutamate biosensor detects activity and circadian rhythm dependent biomarkers of pathogenesis in Mecp2 null mice. Johnston MV, Ammanuel S, O'Driscoll C, Wozniak A, Naidu S, Kadam SD (2014). WONOEP appraisal: new genetic approaches to study epilepsy. Rossignol E, Kobow K, Simonato M, Loeb JA, Grisar T, Gilby KL, Vinet J, Kadam SD, Becker AJ (2014). Circadian cycle-dependent EEG biomarkers of pathogenicity in adult mice following prenatal exposure to in utero inflammation. 9, 173.Īdler DA, Ammanuel S, Lei J, Dada T, Borbiev T, Johnston MV, Kadam SD, Burd I (2014). Age- and sex-dependent susceptibility to phenobarbital-resistant neonatal seizures: role of chloride co-transporters. Kang SK, Markowitz GJ, Kim ST, Johnston MV, Kadam SD (2015). Heightened Delta Power during Slow-Wave-Sleep in Patients with Rett Syndrome Associated with Poor Sleep Efficiency. 3, 101.Īmmanuel S, Chan WC, Adler DA, Lakshamanan BM, Gupta SS, Ewen JB, Johnston MV, Marcus CL, Naidu S, Kadam SD (2015). Neonatal Seizures: Impact on Neurodevelopmental Outcomes. Pre-Clinical Models of Acquired Neonatal Seizures: Differential Effects of Injury on Function of Chloride Co-Transporters. Acute TrkB inhibition rescues phenobarbital-resistant seizures in a mouse model of neonatal ischemia. Temporal progression of evoked field potentials in neocortical slices after unilateral hypoxia-ischemia in perinatal rats: Correlation with cortical epileptogenesis. Lab Website: Kadam Lab Related Links Google Scholar Profile Research Publications Kadam is a current member of the Translational Research Task Force for International League against Epilepsy (ILAE). She is also involved in collaborative studies investigating the role of MeCP2 in epileptogenesis and activity-dependent glutamate homeostasis in-vivo in models of Rett syndrome and the role of in-utero inflammation in developmental disabilities and epileptogenesis. Her current research is focused on acute ischemic seizures in neonates and investigating the role of chloride in co-transporters in the evolution of refractoriness following ischemia in the neonatal period.Īnother focus in her laboratory has been developing protocols to analyze quantitative EEGs (qEEG) using spectral analysis and correlating them to synchronous behavioral states over circadian cycles using 24h continuous EEGs. She has successfully characterized a new mouse model of age-dependent, phenobarbital-resistant seizures using the gold-standard of EEG based quantification of acute seizure burdens. Kadam is interested in investigating mechanisms, underlying epileptogenesis in animal models of developmental disabilities with the goal to test novel therapies. Using the expertise gained during her pre-doctoral training in the Dudek Laboratory, she established a first of its kind: in-vivo mouse electroencephalogram (EEG) laboratory at the Kennedy Krieger Institute in 2009: with capabilities of recording chronic and continuous video/EMG/EEGs.ĭr. Kadam's doctoral research involved the study of epileptogenesis using in vivo ECOG monitoring using telemetry and in vitro slice electrophysiology in a rat model of perinatal hypoxia-ischemia.